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Rick Lewis' publications
    Diethmaier, C., Newman, J.A., Kovács, A.T., Kaever, V., Herzberg, C., Rodrigues, C., Boonstra, M., Kuipers, O.P., Lewis, R.J., Stülke, J. (2013) The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis. J Bacteriol. 196(2):265-75. [Pubmed]
    Newman, J.A., Lewis, R.J. (2013) Exploring the role of SlrR and SlrA in the SinR epigenetic switch. Commun Integr Biol 6: e25658. [PDF]
    Harris, J.R., Soliakov A., Lewis R.J. (2013) In vitro fibrillogenesis of collagen type I in varying ionic and pH conditions. Micron. 49:60-8. [Pubmed]
    Newman, J.A., Rodrigues, C., Lewis, R.J. (2013) Molecular basis of SinR activity, the master regulator of biofilm formation in Bacillus subtilis. J. Biol. Chem. 288(15):10766-78. [Pubmed]
    Liebal, U.W., Millat, T., Marles-Wright, J., Lewis, R.J., Wolkenhauer O. (2013) Simulations of stressosome activation emphasize allosteric interactions between RsbR and RsbT. BMC Syst Biol 7:3.[Pubmed]
    Pitts, A.C., Tuck, A.R., Faulds-Pain, A., Lewis, R.J. & Marles-Wright, J. (2012) Structural insight into the Clostridium difficile ethanolamine utilisation microcompartment. PLOS One 7(10).[Pubmed]
    Lehnik-Habrink M, Lewis RJ, Mäder U, Stülke J. (2012) RNA degradation in Bacillus subtilis: an interplay of essential endo- and exoribonucleases. Mol Microbiol. 84, 1005-17. [Pubmed]
    McKee LS, Peña MJ, Rogowski A, Jackson A, Lewis RJ, York WS, Krogh KB, Viksø-Nielsen A, Skjøt M, Gilbert HJ, Marles-Wright J. (2012) Introducing endo-xylanase activity into an exo-acting arabinofuranosidase that targets side chains. Proc Natl Acad Sci U S A. 109, 6537-42. [Pubmed]
    Eberhardt A, Hoyland CN, Vollmer D, Bisle S, Cleverley RM, Johnsborg O, Håvarstein LS, Lewis RJ, Vollmer W (2012) Attachment of capsular polysaccharide to the cell wall in Streptococcus pneumoniae. Microb Drug Resist. 18, 240-55. [Pubmed]
    Pagett, H.E., Abrahams, J.L., Bones, J., O?Donoghue, N., Marles-Wright, J. Lewis, R.J., Harris, J.R., Caldwell, G.S., Rudd, P.M., Clare, A.S. (2012) Structural characterisation of the N-glycan moiety of the barnacle settlement-inducing protein complex (SIPC). J. Exp. Biol. 215, 1192-1198. [Publisher]
    Quin, M.B., Berrisford, J.M., Newman, J.A., Basle A., Lewis, R.J., Marles-Wright J. (2012) The Bacterial Stressosome: A Modular System that Has Been Adapted to Control Secondary Messenger Signaling. Structure 20, 350-63. [Pubmed]
    Newman, J.A., Hewitt, L., Rodrigues, C., Solovyova, A.S., Harwood, C.R., Lewis RJ. (2012) Dissection of the network of interactions that links RNA processing with glycolysis in the Bacillus subtilis degradosome. J. Mol. Biol. 416, 121-36. [Pubmed]
    Tan, H.L., Glen, E., Topf, A., Hall, D., O'Sullivan, J.J., Sneddon, L., Wren, C., Avery, P., Lewis, R.J., Ten Dijke, P., Arthur, H.M., Goodship, J.A., Keavney, B.D. (2012) Non-synonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. Hum. Mutat. 33, 720-7. [Pubmed]
    Kawai Y., Marles-Wright J., Cleverley R.M., Emmins R., Ishikawa S., Kuwano M., Heinz N., Bui N.K., Hoyland C.N., Ogasawara N., Lewis R.J., Vollmer W., Daniel R.A., Errington J. (2011) A widespread family of bacterial cell wall assembly proteins. EMBOJ 30, 4931-41[Pubmed]
    Newman, J.A., Hewitt, L., Rodrigues, C., Solovyova, A., Harwood, C.R. & Lewis, R.J. (2011) Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1. Structure 19, 1241-51. [Pubmed]
    Harris, J.R., Soliakov, A., Lewis, R.J., Depoix, F., Watkinson, A. & Lakey, J.H. (2011) Alhydrogel® adjuvant, ultrasonic dispersion and protein binding: a TEM and analytical study. Micron 43, 192-200[Pubmed]
    Lehnik-Habrink, M., Newman, J., Rothe, F.M., Solovyova, A.S., Rodrigues, C., Herzberg, C., Commichau, F.M., Lewis, R.J. & Stülke, J. (2011) RNase Y in Bacillus subtilis: a natively disordered protein that is the functional equivalent to RNase E from Escherichia coli. J Bacteriol 193,5431-41.[Pubmed]
    Debieux, C.M., Dridge, E.J., Muellera, C.M., Splatta, P., Paszkiewicza, K., Knight, I., Florance, H., Love, J., Titball, R.W., Lewis, R.J., Richardson, D.J. & Butler, C.S. (2011) A bacterial process for selenium nanosphere assembly. Proc Natl Acad Sci USA 108, 13480-85. [Pubmed]
    Montanier, C.Y., Correia, M.A., Flint, J.E., Zhu, Y., Baslé, A., McKee, L.S., Prates, J.A., Polizzi, S.J., Coutinho, P.M., Lewis, R.J., Henrissat, B., Fontes, C.M. & Gilbert, H.J. (2011) A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization. J Biol Chem 286, 22499-509. [Pubmed]
    Marles-Wright J., Lewis R.J. (2011) The structure of a D-lyxose isomerase from the σ(B) regulon of Bacillus subtilis. Proteins 79, 2015-2019 [Pubmed]
    Cartmell A., McKee L.S., Peña M.J., Larsbrink J., Brumer H., Kaneko S., Ichinose H., Lewis R.J., Viksø-Nielsen A., Gilbert H.J., Marles-Wright J. (2011) The Structure and Function of an Arabinan-specific {alpha}-1,2-Arabinofuranosidase Identified from Screening the Activities of Bacterial GH43 Glycoside Hydrolases. J Biol Chem. 86, 15483-95. [Pubmed]
    Cuskin F., Solovyova A.S., Lewis R.J., Race P.R. (2011) Crystallization and preliminary X-ray analysis of the bacillaene synthase trans-acting acyltransferase PksC. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67, 464-6.[Pubmed]
    Correia M.A., Mazumder K., Bras J.L., Firbank S.J., Zhu Y., Lewis R.J., York W.S., Fontes C.M., Gilbert H.J. (2011) The structure and function of an arabinoxylan-specific xylanase. J Biol Chem. 286, 22510-20. [Pubmed]
    Harris JR, Lewis RJ, Baik C, Pokrajac L, Billington SJ, Palmer M. (2011). Cholesterol microcrystals and cochleate cylinders: Attachment of pyolysin oligomers and domain 4. J Struct Biol 173, 38-45. [Pubmed]
    Marles-Wright J, Lewis RJ. (2010). The stressosome: molecular architecture of a signalling hub. Biochem Soc Trans. 38,928-33.[Pubmed]
    Gunka, K., Newman, J.A., Commichau, F.M., Herzberg, C., Rodrigues, C., Hewitt, L.,Lewis, R.J. Stulke, J. (2010) Functional Dissection of a Trigger Enzyme: Mutations of the Bacillus subtilis Glutamate Dehydrogenase RocG That Affect Differentially Its Catalytic Activity and Regulatory Properties J Mol 400, 815-827.[Pubmed].
    Lowe EC, Bydder S, Hartshorne RS, Tape HL, Dridge EJ, Debieux CM, Paszkiewicz K, Singleton I, Lewis RJ, Santini JM, Richardson DJ, Butler CS. (2010) Quinol-cytochrome c oxidoreductase and cytochrome c4 mediate electron transfer during selenate respiration in Thauera selenatis. J Biol Chem. 285, 18433-42.[Pubmed]
    Underwood, S., Guan, S., Vijayasubhash, V., Baines, S.D., Graham, L., Lewis, R.J., Wilcox, M.H. & Stephenson, K. (2009) Characterization of the sporulation initiation pathway of Clostridium difficile and its role in toxin production. J. Bacteriol. 191, 7296-7305.[Pubmed]
    Yang, X., Molimau, S., Doherty, G.P., Marles-Wright, J., Rathnagel, R., Hankamer, B., Lewis, R.J., & Lewis, P.J. (2009) The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA. EMBO Rep. 10, 997-1002.[Pubmed]
    Schirner, K., Marles-Wright, J., Lewis, R.J. & Errington, J. (2009) Distinct and essential morphogenic functions for wall- and lipo-teichoic acids in Bacillus subtilis. EMBO J 28, 830-842.[Pubmed]
    Pané-Farré, J., Jonas, B., Hardwick, S.W., Gronau, K., Lewis, R.J., Hecker, M. & Engelmann, S. (2009) Role of RsbU in controlling SigB activity in Staphylococcus aureus following alkaline stress. J. Bacteriol. 191, 2561-2573.[Pubmed]
    Montanier, C., van Bueren, A.L., Dumon, C., Flint, J.E., Correia, M.A., Prates, J.A., Firbank, S.J., Lewis, R.J., Grondin, G.G., Ghinet, M.G., Gloster, T.M., Herve, C., Knox, J.P., Talbot, B.G., Turkenburg, J.P., Kerovuo, J., Brzezinski, R., Fontes, CM., Davies, G.J., Boraston, A.B. & Gilbert, H.J. (2009). Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function. Proc Natl Acad Sci USA. 106, 3065-3070.[Pubmed]
    Baur, S., Marles-Wright, J., Buckenmaier, S., Lewis, R.J. & Vollmer, W. (2009) Synthesis of CDP- activated ribitol for teichoic acid precursors in Streptococcus pneumoniae. J. Bacteriol. 191, 1200-1210.[Pubmed]
    Emami, K., Topakas, E., Nagy, T., Henshaw, J., Jackson, K. A., Nelson, K. E., Mongodin, E. F., Murray, J.W., Lewis, R.J. & Gilbert, H.J. (2009) Regulation of the xylan-degrading apparatus of Cellvibrio japonicus by a novel two-component system.J. Biol. Chem. 284, 1086-1096.[Pubmed]
    Marles-Wright, J. & Lewis, R.J. (2008) The Bacillus subtilis stressosome: A signal integration and transduction hub. Commun. Integr. Biol. 1, 182-184.[Pubmed]
    Marles-Wright, J., Grant, T., Delumeau, O., van Duinen, G., Firbank, S.J., Lewis, P.J., Murray, J.W., Newman, J.A., Quin, M.B., Rohou, A., Tichelaar, W., van Heel, M. & Lewis, R.J. (2008) Molecular architecture of the "stressosome," a signal integration and transduction hub. Science 322, 92-96.[Pubmed]
    Firbank, S.J., Wardle, J., Heslop, P, Lewis, R.J. & Connolly, B.A. (2008) Uracil recognition in archaeal DNA polymerases captured by X-ray crystallography. J. Mol. Biol. 381, 529-539.[Pubmed]
    Dumon, C., Varvak, A., Wall, M.A., Flint, J.E., Lewis, R.J., Lakey, H.J., Luginbuhl, P., Healey, S., Todaro, T., DeSantis, G., Sun, M., Parra-Gessert, L., Tan, X., Weiner, D.P. & Gilbert, H.J. (2008) Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure. J. Biol. Chem. 283, 21621-21628.[Pubmed]
    Correia, M.A.A., Prates, J.A.M., Brás, J., Fontes, C.M.G.A., Newman, J.A., Lewis, R.J., Gilbert, H.J. & Flint, J.E. (2008) Crystal structure of a cellulosomal family 3 carbohydrate esterase from Clostridium thermocellum provides insights into the mechanism of substrate recognition. J. Mol. Biol. 379, 64-72.[Pubmed]
    Quin, M., Newman, J., Firbank, S., Lewis, R.J. & Marles-Wright, J. (2008) Crystallization and preliminary X-ray analysis of RsbS from Moorella thermoacetica at 2.5 ? resolution. Acta Crystallogr. F64, 196-199.[Pubmed]
    Vardakou, M., Dumon, C., Murray, J.W., Christakopoulos, P., Weiner, D.P., Juge, N. Lewis, R.J., Gilbert H.J. & Flint, J.E. (2008) Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases. J. Mol. Biol. 375, 1293-1305.[Pubmed]
    Marles-Wright, J. & Lewis, R.J. (2007) Stress responses of bacteria. Curr Opin Struct Biol. 17, 755-760.[Pubmed]
    Gill, S., O'Neill, R., Lewis, R. J. & Connolly, B. A. (2007) Interaction of the family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases. J. Mol. Biol. 372, 855-863. [Pubmed]
    Hardwick, S.W., Pané-Farré, J., Delumeau, O., Marles-Wright, J., Hecker, M. & Lewis, R.J. (2007) Structural and functional characterization of partner switching regulating the environmental stress response in Bacillus subtilis. J. Biol. Chem 282, 11562-11572.[Pubmed]
    Delumeau, O., Chen, C.-C., Murray, J.W., Yudkin, M.D. & Lewis, R.J. (2006) High-molecular-weight complexes of RsbR and paralogues in the environmental signaling pathway of Bacillus subtilis. J. Bacteriol. 188, 7885-7892.[Pubmed]
    Xie, H., Flint, J., Vardakou, M. Lakey, J.H., Lewis, R.J., Gilbert, H.J. & Dumon, C. (2006) Probing the structural basis for the difference in thermostability displayed by family 10 xylanases. J. Mol. Biol. 360, 156-167.[Pubmed]
    Dridge, E.J., Richardson, D.J., Lewis, R.J. & Butler, C.S. (2006) Developing structure-based models to predict substrate specificity of D-group (Type II) molybdenum enzymes: application to a molybdo-enzyme of unknown function from Archaeoglobus fulgidus. Biochem. Soc. Trans. 34, 118-121.[Pubmed]
    Pané-Farré, J., Lewis, R.J. & Stulke, J. (2005) The RsbRST stress module in bacteria: a signalling system that may interact with different output modules. J. Mol. Microbiol. Biotech. 9, 65-77.[Pubmed]
    Murray, J. W., Delumeau, O. & Lewis, R.J. (2005) Structure of a nonheme globin in environmental stress signaling.Proc. Natl. Acad. Sci. (USA) 102, 17320-17325.[Pubmed]
    Vardakou, M., Flint, J., Christakopoulos, P., Lewis, R.J., Gilbert, H.J. & Murray, J. W. (2005) Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases. J. Mol. Biol. 352, 1060-1069.[Pubmed]
    Stephenson, K. & Lewis, R. J. (2005) Molecular insights into the initiation of sporulation in Gram-positive bacteria: new technologies for an old phenomenon. FEMS Microbiol Rev. 29, 281-301. [Pubmed]
    Delumeau, O. Dutta, S., Brigulla, M., Kuhnke, G., Hardwick, S., Volker, U., Yudkin, M. D & Lewis, R. J. (2004) Functional and structural characterization of RsbU, a stress signaling protein phosphatase 2C. J Biol Chem 279, 40927-37. [Pubmed]
    Dong, T. C., Cutting, S. M. & Lewis, R. J. (2004) DNA-binding studies on the Bacillus subtilis transcriptional regulator and AbrB homologue, SpoVT. FEMS Microbiol. Letts. 233, 247-56.[Pubmed]
    Muchova, K., Lewis, R. J., Perecko, D., Brannigan, J. A., Ladds, J. C., Leech, A., Wilkinson, A. J. & Barak, I. (2004) Dimer-induced signal propagation in Spo0A. Molecular Microbiology 53, 829-42[Pubmed]
    Chen, C.-C., Lewis, R. J., Harris, R., Yudkin, M. D. & Delumeau, O. (2003) A supramolecular complex in the environmental stress signaling pathway of Bacillus subtilis. Molecular Microbiology 49, 1657-1669.[Pubmed]
    Ladds, J. C., Muchova, K., Blaskovic, D., Lewis, R. J., Brannigan, J. A., Wilkinson, A. J. & Barak, I. (2003) Response regulator Spo0A from Bacillus subtilis is heterologously phosphorylated in Escherichia coli. FEMS Microbiology Letters 223, 153-157.[Pubmed]
    Dutta, S. & Lewis, R. J. (2003) Crystallisation and preliminary crystallographic analysis of the kinase-recruitment domain of the PP2C-type phosphatase, RsbU. Acta crystallographica D59, 191-193. [Pubmed]
    Delumeau, O., Lewis, R. J. &. Yudkin, M. D. (2002) Protein-protein interactions that regulate the energy stress activation of sigB in Bacillus subtilis. Journal of Bacteriology 184, 5583-5589.[Pubmed]
    Muchova, K., Kutejova, Scott, D. J., Brannigan, J. A., Lewis, R. J., Wilkinson, A. J. & Barak, I. (2002) Oligomerization of the Bacillus subtilis division protein DivIVA. Microbiology 148, 807-81.[Pubmed]
    Lewis, R. J., Scott, D. J., Brannigan, J. A., Ladds, J. C., Cervin, M. A., Spiegelman, G. B., Hoggett, J. A., Barak, I. & Wilkinson, A. J. (2002) Dimer formation and transcription activation in the sporulation response regulator Spo0A. Journal of Molecular Biology 316, 235-245.[Pubmed]
    Seavers, P. R., Lewis, R. J., Brannigan, J. A., Verschueren, K. H. G., Murshudov, G. N. & Wilkinson, A. J. (2001) Structure of the Bacillus cell fate determinant SpoIIAA in phosphorylated and unphosphorylated forms. Structure 9, 605-614.[Pubmed]
    Johnson, L. N. & Lewis, R. J. (2001) The structural basis for control by phosphorylation. Chemical Reviews 101, 2209-2242.[Pubmed]
    Lewis, R. J., Brannigan, J. A., Barak, I. & Wilkinson, A. J. (2001) Lessons and questions from the structure of the Spo0A activation domain:response. Trends in Microbiology 9, 150-151.[Publisher].
    Ducros, V.M.-A., Lewis, R. J., Verma, C. S., Dodson, E. J., Leonard, G., Turkenburg, J. P., Murshudov, G. N., Wilkinson, A. J. & Brannigan, J. A. (2001) Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis. Journal of Molecular Biology. 306, 757-769.[Pubmed]
    Seavers, P. R., Lewis, R. J., Brannigan, J. A. & Wilkinson, A. J. (2001) Crystallisation and preliminary X-ray analysis of the sporulation factor SpoIIAA in both its native and phosphorylated forms. Acta Crystallographica. D57, 292-295.[Pubmed]
    Lewis, R. J., Krzywda, S., Brannigan, J. A., Turkenburg, J. P., Muchova, K., Dodson, E. J., Barak, I., & Wilkinson, A. J. (2000) The trans-activation domain of the sporulation response regulator Spo0A, revealed by X-ray crystallography. Molecular Microbiology 38, 198-212.[Pubmed]
    Hewitt, L., Kasche, V., Lummer, K., Lewis, R. J., Murshudov, G. N., Verma, C. S., Dodson, G. G. & Wilson, K. S. (2000) Structure of a slow processing precursor penicillin acylase from Escherichia coli reveals the linker peptide blocking the active site cleft. Journal of Molecular Biology 302, 887-898[Pubmed]
    Lewis, R. J., Muchova, K., Brannigan, J. A., Barak, I., Leonard, G. & Wilkinson, A. J. (2000) Domain swapping in the sporulation response regulator, Spo0A. Journal of Molecular Biology 297, 757-770.[Pubmed]
    Schmeisser, F., Brannigan, J. A., Lewis, R. J., Wilkinson, A. J., Youngman, P. & Barak, I. (2000) A new mutation in spo0A with intragenic suppressors in the effector domain. FEMS Microbiology Letters 185, 123-128.[Pubmed]
    Lewis, R. J., Brannigan, J. A., Muchova, K., Barak, I. & Wilkinson, A. J. (1999) Phosphorylated aspartate in the crystal structure of a response regulator protein. Journal of Molecular Biology 294, 9-15.[Pubmed]
    Scott, D. J., Leejeerajumnean, S., Brannigan, J. A., Lewis, R. J., Wilkinson, A. J. & Hoggett, J. G. (1999) Quaternary re-arrangement analysed by spectral enhancement: the interaction of a sporulation repressor with its antagonist. Journal of Molecular Biology 293, 997-1004.[Pubmed]
    Scott, D. J., Leejeerajumnean, S., Brannigan, J. A., Lewis, R. J., Wilkinson, A. J. & Hoggett, J. G. (1999) Towards deconvoluting the interactions of the B. subtilis sporulation proteins SinR and SinI using tryptophan analogue incorporated proteins. Progress in Colloid and Polymer Science 113, 209-211.[Publisher].
    Rao, K. N., Hegde, S. S., Lewis, R. J. & Suresh, C. G. (1999) Crystallisation and preliminary X-ray diffraction studies of a Bowman-Birk inhibitor from Vigna unguiculata. Acta Crystallographica D55, 1920-1922.[Pubmed]
    Muchova, K., Lewis, R. J., Brannigan, J. A., Offen, W. A., Brown, D. P., Barak, I., Youngman, P. & Wilkinson, A. J. (1999) Crystallisation of the regulatory and effector domains of the key sporulation response regulator Spo0A. Acta Crystallographica D55, 671-676.[Pubmed]
    Lewis, R. J., Brannigan, J. A., Offen, W. A., Smith, I. & Wilkinson, A. J. (1998) An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex.Journal of Molecular Biology 283, 907-912.[Pubmed]
    Ducros, V. M.-A., Brannigan, J. A., Lewis, R. J. & Wilkinson, A. J. (1998) Bacillus subtilis regulatory protein GerE. Acta Crystallographica D54, 1453-1455.[Pubmed]
    Cervin, M. A., Lewis, R. J., Brannigan, J. A. & Spiegelman, G. B. (1998) The Bacillus subtilis regulator SinR inhibits spoIIG promoter transcription in vitro without displacing RNA polymerase. Nucleic Acids Research 26, 3806-3812.[Pubmed]
    Harper, A., Brannigan, J. A., Buck, M., Hewitt, L., Lewis, R. J., Moore, M. H. & Schneider, B. (1998) Structure of d(TGCGCA)2 and a comparison with other DNA hexamers. Acta Crystallographica D54, 1273-1284.[Pubmed]
    Lewis, R. J. (1998) An evolutionary link between sporulation and prophage induction revealed by X-ray crystallography. Journal of General Physiology and Biophysics 17S1, 33.[Pubmed]
    Muchova, K., Lewis, R. J., Brannigan, J. A., Schmeisser, F., Wilkinson, A. J. & Barak, I. (1998) Primary response regulator Spo0A. Journal of General Physiology and Biophysics 17S1, 34-36. [Pubmed]
    Hewitt, L., Lewis, R. J. & Dodson, E. J. (1998) The inhibition of matrix metalloproteases revealed by X-ray crystallography. Journal of General Physiology and Biophysics 17S1, 46-49.[Pubmed]
    Mernik, N., Lewis, R., Kollarova, M., Mikulasova, D. & Kadlecova, Z. (1998) Characterisation and crystallisation of the malate dehydrogenase from Streptomyces aureofaciens. Journal of General Physiology and Biophysics 17S1, 49-51.[Pubmed]
    Davies, G. J., Ducros, V., Lewis, R. J., Borchert, T. V. & Schulein, M. (1997) Oligosaccharide specificity of a family 7 endoglucanase: insertion of potential sugar-binding subsites. Journal of Biotechnology 57, 91-100.[Pubmed]
    Lewis, R. J., Brannigan, J. A., Smith, I. & Wilkinson, A. J. (1996) Crystallisation and preliminary crystallographic analysis of SinR, a key regulator of sporulation in Bacillus, complexed with its antagonist, SinI. FEBS Letters 378, 98-100.[Pubmed]
    Lewis, R. J., Tsai, F. T. F. & Wigley, D. B. (1996) Molecular mechanisms of drug inhibition of DNA gyrase. Bioessays 18, 661-671.[Pubmed]
    Lewis, R. J., Singh, O. M. P., Smith, C. V., Maxwell, A., Skarzynski, T., Wonacott, A. J. & Wigley, D. B. (1996) The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography. EMBO Journal 15, 1412-1420.[Pubmed]
    Lewis, R. J., Singh, O. M. P., Smith, C. V., Maxwell, A., Skarzynski, T., Wonacott, A. J. & Wigley, D. B. (1994) Crystallisation of inhibitor complexes of an N-terminal 24 kDa fragment of the E. coli DNA gyrase B protein. Journal of Molecular Biology 241, 128-130[Pubmed]
    Rowlands, D., Logan, D., Abu-Ghazaleh, R., Blakemore, W., Curry, S., Jackson, T., King, A., Lea, S., Lewis, R., Newman, J., Parry, N., Stuart, D. & Fry, E. (1994) The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions. Archives in Virology S9, 51-58.[Pubmed]
    Logan, D., Abu-Ghazaleh, R., Blakemore, W., Curry, S., Jackson, T., King, A., Lea, S., Lewis, R., Newman, J., Parry, N., Rowlands, D., Stuart, D. & Fry, E. (1993). The structure of a major immunogenic site on foot and mouth disease virus. Nature 362, 566-568.[Pubmed]
    Fry, E., Logan, D., Abu-Ghazaleh, R., Blakemore, W., Curry, S., Jackson, T., Lea, S., Lewis, R., Newman, J., Parry, N., Rowlands, D., King, A. & Stuart, D. (1992) Molecular studies on the structure of foot and mouth disease virus. In Protein Engineering (Ed. P. Goodenough), pp 71-80, CPL Scientific Press Ltd, Newbury, U.K.
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Highlights

February 2014
JBC Best paper of the year 2013 awarded to Pr. Rick Lewis
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January 2014
2014 is the year of Crystallography
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January 2014
CCP4 Study Weekend
3-5th of January, Nottingham University Read more...

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