Arnaud Basle’s publications

  1. Piergentili, C, Ross, J, He, D, Gallagher, KJ, Stanley, WA, Adam, L et al.. Dissecting the structural and functional roles of a putative metal entry site in encapsulated ferritins. J. Biol. Chem. 2020; :. doi: 10.1074/jbc.RA120.014502. PubMed PMID:32878987 .
  2. Ndeh, D, Baslé, A, Strahl, H, Yates, EA, McClurgg, UL, Henrissat, B et al.. Author Correction: Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nat Commun. 2020;11 (1):4396. doi: 10.1038/s41467-020-18097-1. PubMed PMID:32859948 PubMed Central PMC7455702.
  3. Crouch, LI, Liberato, MV, Urbanowicz, PA, Baslé, A, Lamb, CA, Stewart, CJ et al.. Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. Nat Commun. 2020;11 (1):4017. doi: 10.1038/s41467-020-17847-5. PubMed PMID:32782292 PubMed Central PMC7419316.
  4. Assaad, S, Avrillon, V, Fournier, ML, Mastroianni, B, Russias, B, Swalduz, A et al.. High mortality rate in cancer patients with symptoms of COVID-19 with or without detectable SARS-COV-2 on RT-PCR. Eur. J. Cancer. 2020;135 :251-259. doi: 10.1016/j.ejca.2020.05.028. PubMed PMID:32540204 PubMed Central PMC7275994.
  5. Barwinska-Sendra, A, Garcia, YM, Sendra, KM, Baslé, A, Mackenzie, ES, Tarrant, E et al.. An evolutionary path to altered cofactor specificity in a metalloenzyme. Nat Commun. 2020;11 (1):2738. doi: 10.1038/s41467-020-16478-0. PubMed PMID:32483131 PubMed Central PMC7264356.
  6. Madej, M, White, JBR, Nowakowska, Z, Rawson, S, Scavenius, C, Enghild, JJ et al.. Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis. Nat Microbiol. 2020;5 (8):1016-1025. doi: 10.1038/s41564-020-0716-y. PubMed PMID:32393857 .
  7. Vollmar, M, Parkhurst, JM, Jaques, D, Baslé, A, Murshudov, GN, Waterman, DG et al.. The predictive power of data-processing statistics. 2020;7 (Pt 2):342-354. doi: 10.1107/S2052252520000895. PubMed PMID:32148861 PubMed Central PMC7055369.
  8. Crawshaw, AD, Baslé, A, Salgado, PS. A practical overview of molecular replacement: Clostridioides difficile PilA1, a difficult case study. Acta Crystallogr D Struct Biol. 2020;76 (Pt 3):261-271. doi: 10.1107/S2059798320000467. PubMed PMID:32133990 PubMed Central PMC7057214.
  9. Ndeh, D, Baslé, A, Strahl, H, Yates, EA, McClurgg, UL, Henrissat, B et al.. Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nat Commun. 2020;11 (1):646. doi: 10.1038/s41467-020-14509-4. PubMed PMID:32005816 PubMed Central PMC6994673.
  10. Cartmell, A, Muñoz-Muñoz, J, Briggs, JA, Ndeh, DA, Lowe, EC, Baslé, A et al.. Author Correction: A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Nat Microbiol. 2019;4 (11):2021-2023. doi: 10.1038/s41564-019-0584-5. PubMed PMID:31541200 .
  11. Briliūtė, J, Urbanowicz, PA, Luis, AS, Baslé, A, Paterson, N, Rebello, O et al.. Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci. Nat Microbiol. 2019;4 (9):1571-1581. doi: 10.1038/s41564-019-0466-x. PubMed PMID:31160824 .
  12. Labourel, A, Baslé, A, Munoz-Munoz, J, Ndeh, D, Booth, S, Nepogodiev, SA et al.. Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II. J. Biol. Chem. 2019;294 (19):7711-7721. doi: 10.1074/jbc.RA118.006626. PubMed PMID:30877196 PubMed Central PMC6514610.
  13. Fleming, JR, Schupfner, M, Busch, F, Baslé, A, Ehrmann, A, Sterner, R et al.. Evolutionary Morphing of Tryptophan Synthase: Functional Mechanisms for the Enzymatic Channeling of Indole. J. Mol. Biol. 2018;430 (24):5066-5079. doi: 10.1016/j.jmb.2018.10.013. PubMed PMID:30367843 .
  14. Cartmell, A, Muñoz-Muñoz, J, Briggs, JA, Ndeh, DA, Lowe, EC, Baslé, A et al.. A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation. Nat Microbiol. 2018;3 (11):1314-1326. doi: 10.1038/s41564-018-0258-8. PubMed PMID:30349080 PubMed Central PMC6217937.
  15. Abellón-Ruiz, J, Zahn, M, Baslé, A, van den Berg, B. Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33. Acta Crystallogr D Struct Biol. 2018;74 (Pt 9):852-860. doi: 10.1107/S205979831800904X. PubMed PMID:30198896 .
  16. Pathania, M, Acosta-Gutierrez, S, Bhamidimarri, SP, Baslé, A, Winterhalter, M, Ceccarelli, M et al.. Unusual Constriction Zones in the Major Porins OmpU and OmpT from Vibrio cholerae. Structure. 2018;26 (5):708-721.e4. doi: 10.1016/j.str.2018.03.010. PubMed PMID:29657131 .
  17. Ndeh, D, Rogowski, A, Cartmell, A, Luis, AS, Baslé, A, Gray, J et al.. Corrigendum: Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature. 2017;548 (7669):612. doi: 10.1038/nature23659. PubMed PMID:29411780 .
  18. Baslé, A, El Ghazouani, A, Lee, J, Dennison, C. Insight into Metal Removal from Peptides that Sequester Copper for Methane Oxidation. Chemistry. 2018;24 (18):4515-4518. doi: 10.1002/chem.201706035. PubMed PMID:29365216 PubMed Central PMC5947558.
  19. Aunkham, A, Zahn, M, Kesireddy, A, Pothula, KR, Schulte, A, Baslé, A et al.. Structural basis for chitin acquisition by marine Vibrio species. Nat Commun. 2018;9 (1):220. doi: 10.1038/s41467-017-02523-y. PubMed PMID:29335469 PubMed Central PMC5768706.
  20. Barwinska-Sendra, A, Baslé, A, Waldron, KJ, Un, S. A charge polarization model for the metal-specific activity of superoxide dismutases. Phys Chem Chem Phys. 2018;20 (4):2363-2372. doi: 10.1039/c7cp06829h. PubMed PMID:29308487 PubMed Central PMC5901066.
  21. Unterlass, JE, Wood, RJ, Baslé, A, Tucker, J, Cano, C, Noble, MME et al.. Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). Oncotarget. 2017;8 (61):104478-104491. doi: 10.18632/oncotarget.22327. PubMed PMID:29262655 PubMed Central PMC5732821.
  22. Luis, AS, Briggs, J, Zhang, X, Farnell, B, Ndeh, D, Labourel, A et al.. Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides. Nat Microbiol. 2018;3 (2):210-219. doi: 10.1038/s41564-017-0079-1. PubMed PMID:29255254 PubMed Central PMC5784806.
  23. Baslé, A, Hewitt, L, Koh, A, Lamb, HK, Thompson, P, Burgess, JG et al.. Crystal structure of NucB, a biofilm-degrading endonuclease. Nucleic Acids Res. 2018;46 (1):473-484. doi: 10.1093/nar/gkx1170. PubMed PMID:29165717 PubMed Central PMC5758888.
  24. Abellón-Ruiz, J, Kaptan, SS, Baslé, A, Claudi, B, Bumann, D, Kleinekathöfer, U et al.. Structural basis for maintenance of bacterial outer membrane lipid asymmetry. Nat Microbiol. 2017;2 (12):1616-1623. doi: 10.1038/s41564-017-0046-x. PubMed PMID:29038444 .
  25. Kryshtafovych, A, Albrecht, R, Baslé, A, Bule, P, Caputo, AT, Carvalho, AL et al.. Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Proteins. 2018;86 Suppl 1 :27-50. doi: 10.1002/prot.25392. PubMed PMID:28960539 PubMed Central PMC5820184.
  26. Munoz-Munoz, J, Cartmell, A, Terrapon, N, Baslé, A, Henrissat, B, Gilbert, HJ et al.. An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins. J. Biol. Chem. 2017;292 (32):13271-13283. doi: 10.1074/jbc.M117.794578. PubMed PMID:28637865 PubMed Central PMC5555188.
  27. Cartmell, A, Lowe, EC, Baslé, A, Firbank, SJ, Ndeh, DA, Murray, H et al.. How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (27):7037-7042. doi: 10.1073/pnas.1704367114. PubMed PMID:28630303 PubMed Central PMC5502631.
  28. Baslé, A, Platsaki, S, Dennison, C. Visualizing Biological Copper Storage: The Importance of Thiolate-Coordinated Tetranuclear Clusters. Angew. Chem. Int. Ed. Engl. 2017;56 (30):8697-8700. doi: 10.1002/anie.201703107. PubMed PMID:28504850 PubMed Central PMC5519932.
  29. Temple, MJ, Cuskin, F, Baslé, A, Hickey, N, Speciale, G, Williams, SJ et al.. A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: Unique substrate conformation drives specificity of the key endo-1,6-β-glucanase. J. Biol. Chem. 2017;292 (25):10639-10650. doi: 10.1074/jbc.M117.787606. PubMed PMID:28461332 PubMed Central PMC5481569.
  30. Ndeh, D, Rogowski, A, Cartmell, A, Luis, AS, Baslé, A, Gray, J et al.. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature. 2017;544 (7648):65-70. doi: 10.1038/nature21725. PubMed PMID:28329766 PubMed Central PMC5388186.
  31. Glenwright, AJ, Pothula, KR, Bhamidimarri, SP, Chorev, DS, Baslé, A, Firbank, SJ et al.. Structural basis for nutrient acquisition by dominant members of the human gut microbiota. Nature. 2017;541 (7637):407-411. doi: 10.1038/nature20828. PubMed PMID:28077872 PubMed Central PMC5497811.
  32. Vita, N, Landolfi, G, Baslé, A, Platsaki, S, Lee, J, Waldron, KJ et al.. Bacterial cytosolic proteins with a high capacity for Cu(I) that protect against copper toxicity. Sci Rep. 2016;6 :39065. doi: 10.1038/srep39065. PubMed PMID:27991525 PubMed Central PMC5171941.
  33. Unterlass, JE, Baslé, A, Blackburn, TJ, Tucker, J, Cano, C, Noble, MEM et al.. Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget. 2018;9 (17):13139-13153. doi: 10.18632/oncotarget.11487. PubMed PMID:29568346 PubMed Central PMC5862567.
  34. Labourel, A, Crouch, LI, Brás, JL, Jackson, A, Rogowski, A, Gray, J et al.. The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans. J. Biol. Chem. 2016;291 (42):22149-22159. doi: 10.1074/jbc.M116.743948. PubMed PMID:27531750 PubMed Central PMC5063996.
  35. Arunmanee, W, Pathania, M, Solovyova, AS, Le Brun, AP, Ridley, H, Baslé, A et al.. Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis. Proc. Natl. Acad. Sci. U.S.A. 2016;113 (34):E5034-43. doi: 10.1073/pnas.1602382113. PubMed PMID:27493217 PubMed Central PMC5003275.
  36. Venditto, I, Luis, AS, Rydahl, M, Schückel, J, Fernandes, VO, Vidal-Melgosa, S et al.. Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition. Proc. Natl. Acad. Sci. U.S.A. 2016;113 (26):7136-41. doi: 10.1073/pnas.1601558113. PubMed PMID:27298375 PubMed Central PMC4932953.
  37. van den Berg, B, Chembath, A, Jefferies, D, Basle, A, Khalid, S, Rutherford, JC et al.. Structural basis for Mep2 ammonium transceptor activation by phosphorylation. Nat Commun. 2016;7 :11337. doi: 10.1038/ncomms11337. PubMed PMID:27088325 PubMed Central PMC4852598.
  38. Rogowski, A, Briggs, JA, Mortimer, JC, Tryfona, T, Terrapon, N, Lowe, EC et al.. Corrigendum: Glycan complexity dictates microbial resource allocation in the large intestine. Nat Commun. 2016;7 :10705. doi: 10.1038/ncomms10705. PubMed PMID:26848059 PubMed Central PMC4748232.
  39. Zahn, M, Bhamidimarri, SP, Baslé, A, Winterhalter, M, van den Berg, B. Structural Insights into Outer Membrane Permeability of Acinetobacter baumannii. Structure. 2016;24 (2):221-31. doi: 10.1016/j.str.2015.12.009. PubMed PMID:26805524 .
  40. Kryshtafovych, A, Moult, J, Baslé, A, Burgin, A, Craig, TK, Edwards, RA et al.. Some of the most interesting CASP11 targets through the eyes of their authors. Proteins. 2016;84 Suppl 1 :34-50. doi: 10.1002/prot.24942. PubMed PMID:26473983 PubMed Central PMC4834066.
  41. Vita, N, Platsaki, S, Baslé, A, Allen, SJ, Paterson, NG, Crombie, AT et al.. A four-helix bundle stores copper for methane oxidation. Nature. 2015;525 (7567):140-3. doi: 10.1038/nature14854. PubMed PMID:26308900 PubMed Central PMC4561512.
  42. Cuskin, F, Baslé, A, Ladevèze, S, Day, AM, Gilbert, HJ, Davies, GJ et al.. The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan. J. Biol. Chem. 2015;290 (41):25023-33. doi: 10.1074/jbc.M115.681460. PubMed PMID:26286752 PubMed Central PMC4599007.
  43. Rogowski, A, Briggs, JA, Mortimer, JC, Tryfona, T, Terrapon, N, Lowe, EC et al.. Glycan complexity dictates microbial resource allocation in the large intestine. Nat Commun. 2015;6 :7481. doi: 10.1038/ncomms8481. PubMed PMID:26112186 PubMed Central PMC4491172.
  44. Zahn, M, D'Agostino, T, Eren, E, Baslé, A, Ceccarelli, M, van den Berg, B et al.. Small-Molecule Transport by CarO, an Abundant Eight-Stranded β-Barrel Outer Membrane Protein from Acinetobacter baumannii. J. Mol. Biol. 2015;427 (14):2329-39. doi: 10.1016/j.jmb.2015.03.016. PubMed PMID:25846137 .
  45. Cleverley, RM, Barrett, JR, Baslé, A, Bui, NK, Hewitt, L, Solovyova, A et al.. Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nat Commun. 2014;5 :5421. doi: 10.1038/ncomms6421. PubMed PMID:25403286 PubMed Central PMC4243239.
  46. Wilson, WC, Hornig-Do, HT, Bruni, F, Chang, JH, Jourdain, AA, Martinou, JC et al.. A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Hum. Mol. Genet. 2014;23 (23):6345-55. doi: 10.1093/hmg/ddu352. PubMed PMID:25008111 PubMed Central PMC4222368.
  47. Rogowski, A, Baslé, A, Farinas, CS, Solovyova, A, Mortimer, JC, Dupree, P et al.. Evidence that GH115 α-glucuronidase activity, which is required to degrade plant biomass, is dependent on conformational flexibility. J. Biol. Chem. 2014;289 (1):53-64. doi: 10.1074/jbc.M113.525295. PubMed PMID:24214982 PubMed Central PMC3879575.
  48. Badarau, A, Baslé, A, Firbank, SJ, Dennison, C. Investigating the role of zinc and copper binding motifs of trafficking sites in the cyanobacterium Synechocystis PCC 6803. Biochemistry. 2013;52 (39):6816-23. doi: 10.1021/bi400492t. PubMed PMID:24050657 PubMed Central PMC3793899.
  49. Badarau, A, Baslé, A, Firbank, SJ, Dennison, C. Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains. Chem. Commun. (Camb.). 2013;49 (73):8000-2. doi: 10.1039/c3cc42709a. PubMed PMID:23926594 PubMed Central PMC3763678.
  50. Venditto, I, Baslé, A, Luís, AS, Temple, MJ, Ferreira, LM, Fontes, CM et al.. Overproduction, purification, crystallization and preliminary X-ray characterization of the C-terminal family 65 carbohydrate-binding module (CBM65B) of endoglucanase Cel5A from Eubacterium cellulosolvens. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2013;69 (Pt 2):191-4. doi: 10.1107/S1744309113001620. PubMed PMID:23385766 PubMed Central PMC3564627.
  51. Luís, AS, Venditto, I, Temple, MJ, Rogowski, A, Baslé, A, Xue, J et al.. Understanding how noncatalytic carbohydrate binding modules can display specificity for xyloglucan. J. Biol. Chem. 2013;288 (7):4799-809. doi: 10.1074/jbc.M112.432781. PubMed PMID:23229556 PubMed Central PMC3576085.
  52. Cuskin, F, Flint, JE, Gloster, TM, Morland, C, Baslé, A, Henrissat, B et al.. How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity. Proc. Natl. Acad. Sci. U.S.A. 2012;109 (51):20889-94. doi: 10.1073/pnas.1212034109. PubMed PMID:23213210 PubMed Central PMC3529030.
  53. El Ghazouani, A, Baslé, A, Gray, J, Graham, DW, Firbank, SJ, Dennison, C et al.. Variations in methanobactin structure influences copper utilization by methane-oxidizing bacteria. Proc. Natl. Acad. Sci. U.S.A. 2012;109 (22):8400-4. doi: 10.1073/pnas.1112921109. PubMed PMID:22582172 PubMed Central PMC3365152.
  54. Lowe, EC, Baslé, A, Czjzek, M, Firbank, SJ, Bolam, DN. A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system. Proc. Natl. Acad. Sci. U.S.A. 2012;109 (19):7298-303. doi: 10.1073/pnas.1200479109. PubMed PMID:22532667 PubMed Central PMC3358863.
  55. Quin, MB, Berrisford, JM, Newman, JA, Baslé, A, Lewis, RJ, Marles-Wright, J et al.. The bacterial stressosome: a modular system that has been adapted to control secondary messenger signaling. Structure. 2012;20 (2):350-63. doi: 10.1016/j.str.2012.01.003. PubMed PMID:22325782 .
  56. Montanier, CY, Correia, MA, Flint, JE, Zhu, Y, Baslé, A, McKee, LS et al.. A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization. J. Biol. Chem. 2011;286 (25):22499-509. doi: 10.1074/jbc.M110.217372. PubMed PMID:21454512 PubMed Central PMC3121395.
  57. El Ghazouani, A, Baslé, A, Firbank, SJ, Knapp, CW, Gray, J, Graham, DW et al.. Copper-binding properties and structures of methanobactins from Methylosinus trichosporium OB3b. Inorg Chem. 2011;50 (4):1378-91. doi: 10.1021/ic101965j. PubMed PMID:21254756 .
  58. Wager, B, Baslé, A, Delcour, AH. Disulfide bond tethering of extracellular loops does not affect the closure of OmpF porin at acidic pH. Proteins. 2010;78 (14):2886-94. doi: 10.1002/prot.22807. PubMed PMID:20665474 .
  59. Marković-Housley, Z, Basle, A, Padavattan, S, Maderegger, B, Schirmer, T, Hoffmann-Sommergruber, K et al.. Structure of the major carrot allergen Dau c 1. Acta Crystallogr. D Biol. Crystallogr. 2009;65 (Pt 11):1206-12. doi: 10.1107/S0907444909034854. PubMed PMID:19923716 .
  60. Minasov, G, Padavattan, S, Shuvalova, L, Brunzelle, JS, Miller, DJ, Baslé, A et al.. Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains. J. Biol. Chem. 2009;284 (19):13174-84. doi: 10.1074/jbc.M808221200. PubMed PMID:19244251 PubMed Central PMC2676049.
  61. Baslé, A, Rummel, G, Storici, P, Rosenbusch, JP, Schirmer, T. Crystal structure of osmoporin OmpC from E. coli at 2.0 A. J. Mol. Biol. 2006;362 (5):933-42. doi: 10.1016/j.jmb.2006.08.002. PubMed PMID:16949612 .
  62. Miedema, H, Vrouenraets, M, Wierenga, J, Eisenberg, B, Schirmer, T, Baslé, A et al.. Conductance and selectivity fluctuations in D127 mutants of the bacterial porin OmpF. Eur. Biophys. J. 2006;36 (1):13-22. doi: 10.1007/s00249-006-0084-4. PubMed PMID:16858566 .
  63. Baslé, A, Qutub, R, Mehrazin, M, Wibbenmeyer, J, Delcour, AH. Deletions of single extracellular loops affect pH sensitivity, but not voltage dependence, of the Escherichia coli porin OmpF. Protein Eng. Des. Sel. 2004;17 (9):665-72. doi: 10.1093/protein/gzh078. PubMed PMID:15469993 .
  64. Baslé, A, Iyer, R, Delcour, AH. Subconductance states in OmpF gating. Biochim. Biophys. Acta. 2004;1664 (1):100-7. doi: 10.1016/j.bbamem.2004.04.009. PubMed PMID:15238263 .
  65. Simonet, VC, Baslé, A, Klose, KE, Delcour, AH. The Vibrio cholerae porins OmpU and OmpT have distinct channel properties. J. Biol. Chem. 2003;278 (19):17539-45. doi: 10.1074/jbc.M301202200. PubMed PMID:12606562 .
  66. Dé, E, Baslé, A, Jaquinod, M, Saint, N, Malléa, M, Molle, G et al.. A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin. Mol. Microbiol. 2001;41 (1):189-98. doi: 10.1046/j.1365-2958.2001.02501.x. PubMed PMID:11454211 .
  67. Baslé, A, Delcour, AH. Effect of two polyamine toxins on the bacterial porin OmpF. Biochem. Biophys. Res. Commun. 2001;285 (2):550-4. doi: 10.1006/bbrc.2001.5155. PubMed PMID:11444879 .
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